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Elimination of MicrofilariaeThe most effective drugs for this function are the macrocyclic lactone (ML) anthelmintics, i.e.,milbemycin oxime, selamectin, moxidectin and ivermectin. These drugs are the ingredients in normally used heartworm preventives. Though their use as microfilaricides has not yet been approved by the FDA, they are widely used by veterinarians since there are not any approved microfilaricidal drugs currently available. It is recommended that microfilariae favorable dogs being treated using these macrocyclic lactones be hospitalized for at least eight hours after treatment for observation of potential adverse reactions, including those resulting from rapid death of the microfilariae.Circulating microfilariae are usually removed within a couple of weeks by the management of the ML-type drugs mentioned above. Today however, the most widely used microfilaricidal remedy is to just administer ML preventives as normal, and the microfilariae will be eliminated gradually over a period of approximately six to nine months.
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